Consequently, the vast majority of patients die in a short period (6–8 months) ( Singh et al., 2005 Cerbone et al., 2014). There is currently no effective treatment for metastasis. The main goal of treatment is to locally control tumor growth and prevent tumor metastasis and spreading. Most tumors can be treated by irradiation (e.g., radioactive plaque, proton beam), and larger tumors may require eye excision ( Dogrusöz et al., 2017). About half of patients eventually developed blood metastases, often on the liver. (2009) of 8,033 UM patients, tumors were located in the iris in 285 cases (4%), the ciliary body in 492 cases (6%), and the choroid in 7,256 cases (90%). ![]() Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. The iris color spectrum is consistent with the raters’ view, but there is no significant correlation with UM incidence. We obtained satisfactory segmentation results with high consistency with those from experts. Then the iris was analyzed with machine learning methods (random forests and convolutional neural networks) to obtain the corresponding iris color spectra (classification probability). All anterior segment photos were automatically segmented with U-NET, and only the iris regions were retained. However, in all these studies, a remarkably low percentage of patients have brown eyes, so we applied deep learning methods to investigate the correlation between iris color and the prevalence of UM in the Chinese population. Previous studies have shown that light iris color is a predisposing factor for the development of uveal melanoma (UM) in a population of Caucasian ancestry.
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